Drug Interactions: General and Nursing Considerations

In many cases two interacting agents are concurrently administered, but are taken to minimize interactions or side effects. Precautions, such as dosage adjustments, must be taken in this event. Drug interactions are not always adverse, and they are sometimes taken advantage of therapeutically. For example, probenecid can be administered with penicillin to decrease the excretion rate of the penicillin and, therefore, result in higher blood levels of penicillin.